SELECTIVELY DIRECTING THE HUMAN GENOME
TO TREAT & CURE SERIOUS DISEASE

Understanding Nature’s Universal
Operating system

OUR OMEGA EPIGENOMIC PROGRAMMING PLATFORM: EPIZIPS // OMEGA EPIGENOMIC CONTROLLERS // NOVEL DRUG DELIVERY // INDUSTRY-LEADING EXPERTISE

Omega Therapeutics was founded to understand epigenetic regulation in order to systematically control the fundamental biology of gene expression.

We have identified nature’s universal operating system for gene control and have created a new drug development platform to specifically target Insulated Genomic Domains (IGDs).

By co-opting this operating system, we have identified and classified roughly 15,000 IGDs in our genome, created a system of genomic “zip codes” to use IGDs as drug targets, which we call EpiZips™, and have developed Omega Epigenomic Controllers (OECs), a new class of medicine.

Through our OMEGA platform, we have achieved in vivo proof of concept of our OECs in in multiple disease models for various indications that modern gene-based therapies have not been able to address.

OUR BROAD AND TRANSFORMATIVE PLATFORM ALLOWS US TO ADDRESS CONDITIONS INITIALLY SPANNING:

Regenerative medicine.
Recapitulation of developmental and mature-state gene expression to drive cellular regeneration and restore normal function.

Multigenic diseases including immunology.
Regulation of multiple genes within an IGD or across IGDs.

Oncology.
Control of target oncogenes including historically challenging or un-druggable targets in various cancers.

Select monogenic diseases.
Correction of dysregulation in monogenic rare and non-rare diseases.

IGDs AS DRUG TARGETS

IGDs present differently in pristine and diseased states, and we leverage this knowledge to create therapeutic interventions.

Omega Epigenomic Controllers™ can target any aspect of dysregulated IGDs with exquisite specificity

and precisely tune the level of gene expression needed to restore native structure and correct function. In the context of single or complex multigenic diseases, we have proactively engineered nature’s own toolkit to restore healthy biological function.

TUNING GENES BY TARGETING EPIGENOMIC “ZIP CODES”, EPIZIPS, WITHIN IGDs FOR PRECISION GENOMIC CONTROL™

IGDs are nature’s system of organizing genes and controlling their expression, and we have characterized them by their genomic “zip codes”, disease correlations, and mechanisms of action. We call these epigenomic targets EpiZips. By precisely tuning IGDs, our Omega Epigenomic Controllers 

regulate single- or multi-gene expression to desired levels to treat or cure serious disease with high specificity, tunability and durability, all without altering the body’s native nucleic acid sequences.

SPECIFICITY

Through computational techniques including our diverse library of proprietary algorithms and deep-learning techniques, we have identified thousands of potential intervention points to target specific DNA binding domains, IGDs, and their sub-elements and regulators, because we understand their genomic addresses.

TUNABILITY

Our epigenomic controllers are able to tune gene expression individually or collectively, up or down, whereas gene editing or gene therapy have a binary and generally permanent effect, causing genes to remain all the way “on” or “off.”

DURABILITY

We have achieved controllable durability of effect through our use of nature's own epigenetic mechanisms. We can tailor the therapeutic response of our Omega Epigenomic Controllers to last for a few days, a few weeks, or even a few months.

ENGINEERED AND MODULAR, PROGRAMMABLE MRNA-ENCODED THERAPEUTICS DELIVERED BY LNPs TO SPECIFIC TISSUES AND CELLS

Publications and Research Bibliography

SELECT PUBLICATIONS

OMEGA THERAPEUTICS UNIQUELY TARGETS THE BIOLOGICAL ROOT OF DISEASE WITH CLEAR ADVANTAGES:

SPECIFIC, PRECISE, DURABLE, NON-TRANSGENIC,
NON-INTEGRATING, MODULAR