Epigenetics worked through a universal system and we could interrogate that system and therapeutically intervene?
Nature has organized genes and their regulatory elements in conserved 3D structures called Insulated Genomic Domains (IGDs). This is nature’s universal operating system for genomic control, which Omega has therapeutically harnessed, through the OMEGA Epigenomic Programming™ platform, to rationally design and engineer modular, programmable mRNA-encoded epigenetic medicines, Omega Epigenomic Controllers™ (OECs).
Our breakthrough science has enabled us to tap into this universal operating system for genomic control to systematically address and target the most fundamental genomic processes which fuel cellular growth, differentiation and gene expression.
This is the promise of
the OMEGA platform
Nature has organized genes and their regulatory elements in distinct and evolutionary conserved 3D structures called Insulated Genomic Domains (IGDs) to control gene expression. IGDs encompass single or multiple genes and their regulatory elements, and are the fundamental structural and functional units of gene control and cell differentiation and act as the “control room” of biology. They are insulated from outside transcription by CTCF binding. At Omega, we understand the topology and the functionality of these IGDs through both computational and biological insights. We have leveraged proprietary algorithms and machine-learning tools mining our own and public databases to categorize the roughly 15,000 human IGDs and their elements into genomic “zip codes”, called EpiZips™, that we target with high specificity. We understand how they differ between pristine and diseased states, and these insights inform the Company’s approach to IGDs as drug targets to treat and potentially cure disease.
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Omega has created a new category of medicine through its OMEGA Epigenomic Programming platform. We are developing novel engineered and modular mRNA-encoded therapeutics, called Omega Epigenomic Controllers (OECs), that allow us to regulate multiple genes with exquisite specificity, controllable tuning, and duration of effect. Omega’s medicines are being developed to be dosed only as frequently as therapeutically necessary by intervening at the pre-transcriptional level without making changes to native nucleic acid sequences.
This is Precision Genomic Control™
