A LEGACY OF ACHIEVEMENT,
TOWARD A FUTURE OF ACCOMPLISHMENT

WHAT WE STAND FOR

At Omega Therapeutics, we interrogate the central dogma to target the biological root of disease and change its course without altering nucleic acid sequences or the genetic code.

We are focused on precision tuning to activate the human genome’s native capacity to treat and cure diseases — ultimately allowing for the advancement of medicine and a new future of disease management.

WE ARE ON A MISSION TO DELIVER TRANSFORMATIVE GENOMIC MEDICINE TO CURE DISEASES AND HELP PATIENTS.

VALUES

LEADERSHIP

INNOVATION

RESILIENCE

AUTHENTICITY

TRUST

OUR LEADERSHIP TEAM

Mahesh Karande, President & CEO, Board Director of Omega Therapeutics
Mahesh Karande

President & CEO, Board Director

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Mahesh Karande | President & CEO, Board Director

Mahesh Karande is deeply experienced in running biopharma businesses across discovery, preclinical development, clinical development, commercialization and product life cycle management stages. His breadth of therapeutic experience spans cardiovascular and metabolic, oncology, neurosciences, ophthalmology, antibiotics, pain, respiratory and rare and genetic diseases as well as drug and device combinations. He has been involved with more than 10 product launches in the U.S. and across global markets.

He has strong leadership, operational and business-building experiences combined with a global work history spanning the U.S., Europe, Asia and Africa.

Most recently, Mr. Karande was president and CEO of Macrolide Pharmaceuticals from discovery into early development. Earlier, Mr. Karande spent several years at Novartis, leading various U.S. and international business units. Mr. Karande left Novartis to join Intarcia Therapeutics as VP and general manager to lead the launch of its first product — a role he left to take the helm at Macrolide.

Mr. Karande has an M.B.A. from the Wharton School, University of Pennsylvania. He is also a graduate of the Georgia Institute of Technology where he completed his M.S. in engineering and the University of Bombay where he completed undergraduate studies in engineering.

Thomas McCauley, Chief Scientific Officer of Omega Therapeutics
Thomas McCauley

Chief Scientific Officer

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Thomas McCauley | Chief Scientific Officer

Dr. Thomas McCauley joined Omega as chief scientific officer in August 2019. Prior to Omega, he served as CSO at Zikani Therapeutics (formerly Macrolide Pharmaceuticals) and before that at Translate Bio (formerly RaNA Therapeutics).

In these roles, Dr. McCauley was responsible for overall scientific vision, strategic direction and leadership of research and development. He provided scientific, technical and operational oversight for advancement of the company’s oligo, mRNA and novel macrocyclic technology platforms and management of portfolio therapeutic programs in pulmonary, metabolic, genetic and infectious disease.

Previously, Dr. McCauley served as vice president and head of Global Nonclinical Development at Shire Pharmaceuticals, where he made significant contributions to the development and global approvals of many of Shire's products, including Replagal® for Fabry disease, Vpriv® for Gaucher disease, Elaprase® for Hunter syndrome, Firazyr® for hereditary angioedema and Xiidra® for dry eye disease.

Dr. McCauley has more than 19 years of experience in the biotechnology and pharmaceutical industries and has authored more than 40 scientific publications, book chapters and patents. He holds undergraduate and graduate degrees from Cornell University and received his Ph.D. from the University of Alabama at Birmingham.

Christian Cobaugh, VP, Platform and Process Development of Omega Therapeutics
Christian Cobaugh

VP, Platform and Process Development

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Christian Cobaugh | VP, Platform and Process Development

Dr. Christian Cobaugh leads Omega Therapeutics’ drug formulation and delivery, process development and associated analytics.

With more than a decade of experience leading target identification, drug discovery and development in nucleic acid medicines, biologics and small molecules across a broad range of therapeutic areas, Dr. Cobaugh knows that breakthrough products come from great teams realizing the full potential of cutting-edge technology.

Most recently, Dr. Cobaugh was senior director, Discovery Biology and Process Development, at Translate Bio, an mRNA therapeutics company. Prior to that, Dr. Cobaugh led research partnerships and drug discovery teams as a director at CRISPR Therapeutics and Arcturus Therapeutics and as a research scientist at Alexion Pharmaceuticals.

Dr. Cobaugh holds a Ph.D. in cell and molecular biology from the University of Texas-Austin.

Jeffrey Kopacz, VP, Intellectual Property of Omega Therapeutics
Jeffrey Kopacz

VP, Intellectual Property

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Jeffrey Kopacz | VP, Intellectual Property

Jeff Kopacz joined Omega Therapeutics in January of 2019 with more than 17 years of experience in the legal and biopharmaceutical industries.

Prior to joining Omega, Mr. Kopacz served as senior director, senior intellectual property counsel at Alnylam Pharmaceuticals, Inc.

Mr. Kopacz served at Alnylam for 10 years. His primary responsibilities included developing and executing the intellectual property strategy for Alnylam’s therapeutic candidates (seven+ currently in clinical trials, including Givosiran, Fitusiran and Inclisiran) and built the intellectual property portfolio for the world’s first RNAi-approved medicine, Onpattro®. He also helped defend the Alnylam platform intellectual property estate from patent challenges and worked closely with business development supporting various license agreements and collaborations, including Sanofi/Genzyme, Regeneron, Novartis and the Medicines Company.

Prior to joining Alnylam, Mr. Kopacz was an attorney at Edwards Angell Palmer & Dodge LLP (now Locke Lord LLP), where he built the intellectual property estates for numerous commercial products and counseled clients on intellectual property matters in the biotechnology and pharmaceutical industries.

Mr. Kopacz began his biopharmaceutical career at Millennium Pharmaceuticals, now Takeda Pharmaceuticals.

Mr. Kopacz received his undergraduate degree in microbiology for University of Massachusetts at Amherst, his graduate degree in molecular microbiology and immunology from Johns Hopkins University and a law degree from Suffolk University Law School.

Chinmaya Rath, VP, Strategy & Business Development of Omega Therapeutics
Chinmaya Rath

VP, Strategy & Business Development

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Chinmaya Rath | VP, Strategy & Business Development

Chinmaya Rath brings more than 20 years of diverse biopharma experience, working across multiple geographies in corporate strategy, commercial launch, business integration and business development.

Most recently at AstraZeneca, Mr. Rath was the Lynparza Brand Strategy lead for key launches in ovarian cancer. At Novartis, as U.S. brand director for Tasigna, he led “treatment-free remission” and “pediatric indication” launches in CML.

While at Novartis, Mr. Rath was the head of U.S. Oncology Strategy and Operations for ~$6 billion business. He successfully led key strategic endeavors, including the integration of GSK’s U.S. oncology division and the plan to maximize the Global portfolio and assets through prioritization.

Mr. Rath received his MBA in strategy and finance from Warwick Business School, U.K. and an MBA in marketing from Army Institute of Management studies, India. He completed his undergraduate studies in life science with honors from Ravenshaw University, India.

OMEGA THERAPEUTICS BOARD OF DIRECTORS

Noubar Afeyan Ph.D., Co-Founder and Chairman of Omega Therapeutics Board and CEO of Flagship Pioneering
Noubar Afeyan, Ph.D.

Co-Founder and Chairman of the Board, Omega Therapeutics, CEO Flagship Pioneering

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Noubar Afeyan, Ph.D. | Co-Founder and Chairman of the Board, Omega Therapeutics, CEO Flagship Pioneering

Noubar Afeyan has dedicated his career to improving the human condition by systematically creating science-based innovations that serve as the foundation for startup companies. Flagship has fostered the development of more than 100 scientific ventures resulting in $30 billion in aggregate value, thousands of patents and patent applications and more than 50 drugs in clinical development.

Prior to founding Flagship Pioneering, Dr. Afeyan was the founder and CEO of PerSeptive Biosystems, a leader in bio-instrumentation that grew to $100 million in annual revenues. After PerSeptive’s acquisition by Perkin Elmer/Applera Corporation in 1998, he became senior vice president and chief business officer of Applera, where he initiated and oversaw the creation of Celera Genomics. He serves on the boards of a number of public and private Flagship companies, has written numerous scientific publications and is the inventor of more than 80 patents.

Dr. Afeyan was born in Beirut to Armenian parents in 1962, did his undergraduate work at McGill University in Montreal and completed his Ph.D. in biochemical engineering at MIT in 1987. A passionate advocate of the contributions of immigrants to economic and scientific progress, Dr. Afeyan received the Golden Door Award in 2017 from the International Institute of New England in honor of his outstanding contributions to American society as a U.S. citizen of foreign birth.

David Berry, M.D., Ph.D., Co-Founder of Omega Therapeutics and General Partner of Flagship Pioneering
David Berry, M.D., Ph.D.

Co-Founder, Omega Therapeutics, General Partner, Flagship Pioneering

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David Berry, M.D., Ph.D. | Co-Founder, Omega Therapeutics, General Partner, Flagship Pioneering

David Berry joined Flagship Pioneering in 2005 where he is a general partner, focusing on conceiving, creating, resourcing, and launching groundbreaking companies. Dr. Berry has co-founded more than 20 companies across life sciences and sustainability, including Joule, Seres Therapeutics (NASDAQ: MCRB), T2 Biosystems (NASDAQ: TTOO), Indigo Agriculture, Evelo Biosciences, Eleven Biotherapeutics (NASDAQ: EBIO), LS9 (acquired by Renewable Energy Group), Axcella Health and Inari Agriculture. He has served as founding CEO of more than 10 companies, including Seres, Evelo and Axcella.

Dr. Berry received his M.D. from Harvard Medical School and his Ph.D. from MIT in biological engineering.

Rick Young, Ph.D., MIT Professor of Biology and Member of Whitehead Institute
Rick Young, Ph.D.

MIT Professor of Biology, Member, Whitehead Institute

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Rick Young, Ph.D. | MIT Professor of Biology, Member, Whitehead Institute

Dr. Rick Young studies gene regulatory circuitry in health and disease. His research accomplishments range from the development of genome-wide analysis technologies to the discovery of core regulatory circuitry of human embryonic stem cells. He has served as an advisor to the National Institutes of Health, the World Health Organization, the Vatican and numerous scientific societies and journals. Dr. Young has founded and advised companies in the biotechnology and pharmaceutical industry and is currently a member of the board of directors of Syros Pharmaceuticals, Camp4 Therapeutics, Omega Therapeutics and Dewpoint Therapeutics.

Dr. Young received his Ph.D. in molecular biophysics and biochemistry at Yale University, conducted postdoctoral research at Stanford University and joined Whitehead Institute and MIT in 1984.

Paul-Peter Tak, M.D., Ph.D., CEO of Kintai Therapeutics, Venture Partner of Flagship Pioneering
Paul-Peter Tak, M.D., Ph.D.

Kintai Therapeutics, CEO, Venture Partner, Flagship Pioneering

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Paul-Peter Tak, M.D., Ph.D. | Kintai Therapeutics, CEO, Venture Partner, Flagship Pioneering

Spanning a more than 25-year career in the life sciences, Dr. Paul-Peter Tak has created and led multiple companies, including Arthrogen b.v. (Amsterdam, Netherlands) and Tempero Pharmaceuticals (Cambridge, MA) and served as senior vice president of R&D pipeline and as chief immunology officer, development leader and co-chair of the scientific review board at GSK. He served as professor of medicine and chair of the department of clinical immunology and rheumatology at the Academic Medical Centre/University of Amsterdam for 12 years. He is a professor of Medicine at the Amsterdam University Medical Center, honorary professor of Rheumatology at Ghent University, honorary senior visiting fellow at the University of Cambridge and a fellow of the Academy of Medical Sciences in the U.K.

Dr. Tak received his medical degree cum laude from the Free University in Amsterdam and his Ph.D. from Leiden University Medical Center.

Mary Szela TriSalus CEO of Life Sciences
Mary Szela

TriSalus Life Sciences, CEO

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Mary Szela | TriSalus Life Sciences, CEO

Mary Szela has more than 32 years of experience as an executive in the biotechnology and pharmaceutical industry, serving on the board of directors of publicly held companies Receptos Inc., Novo Nordisk and Novelion Therapeutics. Ms. Szela currently serves on the board of Coherus Biosciences, Kura Oncology, Alimera Sciences and TriSalus Life Sciences. Prior to joining TriSalus, Ms. Szela was chief executive officer of Novelion Therapeutics, where she resolved the significant legal, regulatory and compliance issues facing the company and executed a merger to recapitalize the company within the first year.

Ms. Szela earned a B.S. in nursing and an MBA from the University of Illinois at Chicago.

OUR COMPANY

Founded by Flagship Pioneering in 2017, Omega Therapeutics is a preclinical stage genomics medicine enterprise that is transforming medicine and patient care through precision genomic control. Today, we are interrogating the central dogma of biology and illuminating the role of genomic activation at the pretranscriptional level as a new way to treat and potentially cure disease by precisely controlling genomic expression without changing nucleic acid sequences.

Omega has created a foundational proprietary knowledge base of Insulated Genomic Domains (IGDs) and their biological functions in both healthy and diseased states across cell types. IGDs function as the fundamental regulators, or GenomStats™, of the human genome.

This scientific insight drives our discovery and development of genomic modulators, called Omega Controllers™. We engineer them to precisely tune genomic activity to desired therapeutic levels through control of the GenomStats™. This allows us to treat disease without altering the human genetic code.

FOUNDERS Flagship Labs
CHAIRMAN & FOUNDER Noubar Afeyan
FOUNDER David Berry
FOUNDED May 2017
SCIENTIFIC ADVISORS Rudolf Jaenisch & Richard A. Young
M.I.T. and
Whitehead Institute
HEADQUARTERS Cambridge, MA
Scientist at an Omega Controller

OUR INVESTIGATIONS

Using computational biology, we have successfully mapped the IGDs and have been able to identify the correct genomic target for a therapeutic influence.

We are investigating the biology of a range of
diseases to determine how best to intervene with
our Omega Controllers™. Our goal is to redirect the
course of disease through the native capacity of the human genome.

A NEW ERA OF GENOMIC MEDICINE

We are developing a transformative precision therapeutics class for a range of indications, including rare genetic diseases, immunology, inflammation, metabolic diseases and oncology. Most disease results from dysregulation of the genome.

Our distinct model brings together every critical component for success: deeply experienced leadership, a commitment to foundational scientific principles, full capabilities for drug discovery and development, commercialization expertise and professional capital management.

We are united to develop and eventually commercialize the next generation of genomic medicines that are effective, safe and durable.

MOST DISEASE RESULTS FROM DYSREGULATION OF THE GENOME.