SCIENCE Publications

Targeted Epigenomic Control of the MYC Oncogene Robustly Inhibits Survival and Growth of Non-Small Cell Lung Cancer Organoid and Xenograft Models.
Poster Presentation at 2023 Gordon Research Conference on Cancer Genetics and Epigenetics.
A phase 1/2 open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of OTX-2002 as a single agent and in combination with standard of care in patients with hepatocellular carcinoma and other solid tumor types known for association with the MYC oncogene (MYCHELANGELO I)
Poster Presentation at ASCO GI 2023
Drugging the epigenome in the age of precision medicine
Feehley T, O'Donnell CW, Mendlein J, Karande M, McCauley T. Clin Epigenetics. 2023 Jan 11;15(1):6.
Modulation of the MYC Oncogene Using Programmable mRNA Therapeutics as a Novel Therapy for Hepatocellular Carcinoma.
William Senapedis, Kayleigh Gallagher, Elmer Figueroa, Jeremiah Farelli, Robert Lyng, Charles O’Donnell, Joseph Newman, Thomas McCauley.
Novel Epigenetic Targeting of the MYC Oncogene for the Treatment of NSCLC Using Programmable mRNA Therapeutics.
Defne Yarar, Eugine Lee, Houda Belaghzal, Kai-Yuan Chen, Cameron Vergato, Stephen Siecinski, Jeremiah Farelli, Charles O’Donnell, Joseph Newman, Thomas McCauley.
Epigenetic Modulation of the MYC Oncogene as a Potential Novel Therapy for HCC.
William Senapedis, Elmer Figueroa, Kayleigh Gallagher, Jeremiah Farelli, Robert Lyng, Charles O’Donnell, Joseph Newman, Thomas McCauley.
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control.
Hnisz D, Day DS, Young RA. Cell. 2016 Nov 17;167(5):1188-1200. doi: 10.1016/j.cell.2016.10.024. Review.
CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription.
Tang Z, Luo OJ, Li X, Zheng M, Zhu JJ, Szalaj P, Trzaskoma P, Magalska A, Wlodarczyk J, Ruszczycki B, Michalski P, Piecuch E, Wang P, Wang D, Tian SZ, Penrad-Mobayed M, Sachs LM, Ruan X, Wei CL, Liu ET, Wilczynski GM, Plewczynski D, Li G, Ruan Y. Cell. 2015 Dec 17;163(7):1611-27. doi: 10.1016/j.cell.2015.11.024. Epub 2015 Dec 10.
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.
Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA. Cell. 2014 Oct 9;159(2):374-387. doi: 10.1016/j.cell.2014.09.030.
Genome-wide map of regulatory interactions in the human genome.
Heidari N, Phanstiel DH, He C, Grubert F, Jahanbani F, Kasowski M, Zhang MQ, Snyder MP. Genome Res. 2014 Dec;24(12):1905-17. doi: 10.1101/gr.176586.114. Epub 2014 Sep 16.
Activation of proto-oncogenes by disruption of chromosome neighborhoods.
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA. Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024. Epub 2016 Mar 3.
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.
Rao SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I, Omer AD, Lander ES, Aiden EL. Cell. 2014 Dec 18;159(7):1665-80. doi: 0.1016/j.cell.2014.11.021. Epub 2014 Dec 11. Erratum in: Cell. 2015 Jul 30;162(3):687-8.

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