SCIENCE Publications

Durable Upregulation of P1-isoform Hepatocyte Nuclear Factor alpha (HNF4A) Using Novel Epigenomic Controllers

Christopher E. Pedigo, Amy McCurley, Justin Chen, Yaoyu E. Wang, Steve Siecinski, Yoseph Kassa, Chevaun Morrison-Smith, Jeremiah Farelli, Charles W. O’Donnell, Joseph Newman, Jennifer Nelson

Programmable Epigenomic mRNA Therapeutics Enable Multi-gene Up or Down Tuning of α-globin via Regulatory Element Targeting: A Precision Approach for β- and α-Thalassemia Treatment

Houda Belaghzal, Giuliana Castello Coatti, Charles W. O'Donnell, Thomas McCauley

Controlled epigenomic upregulation of CXCL9 and CXCL10 in hepatocellular carcinoma promotes T-cell recruitment

Eugine Lee, Maddy Pacaro, Houda Belaghzal, Cameron Vergato, Daniel F. G. Costa, Pranjali Rumale, Snigdha Kosana, Sam Mildrum, Steve Siecinski, Defne Yarar, Graeme Hodgson

Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models

William Senapedis, Kayleigh M. Gallagher, Elmer Figueroa, Jeremiah D. Farelli, Robert Lyng, J. Graeme Hodgson, Charles W. O’Donnell, Joseph V. Newman, Madison Pacaro, Stephen K. Siecinski, Justin Chen, and Thomas G. McCauley

Tuned Upregulation of Diverse Gene Targets using Programmable Epigenomic Controllers

Poster Presentation at ASGCT 2024

Detection and quantification of site-specific DNA methylation from liquid biopsies as a pharmacodynamic biomarker of OTX-2002, a novel MYC-targeting epigenomic controller

Poster Presentation at AACR 2024

Targeted epigenomic control of MYC as a strategy to treat EGFR inhibitor-resistant NSCLC

Poster Presentation at AACR 2024

Induction of Hepatocyte Nuclear Factor 4 alpha (HNF4α) P1-isoforms Using a Selective Epigenomic Controller

Poster Presentation at AASLD 2023

Targeting CXCL9/CXCL10/CXCL11 Using Novel Epigenomic Controllers for the Treatment of Inflammatory Liver Disease

Poster Presentation at AASLD 2023

Design and Characterization of a Programmable Epigenomic Controller Demonstrating Multiplexed Targeting of the CXCL1-8 Gene Cluster for Treatment of Inflammatory Disorders

Poster Presentation at International mRNA Health Conference

Targeted epigenomic modulation of MYC enhances responses to immune checkpoint and EGFR inhibitors in preclinical models of NSCLC

Poster Presentation at AACR-NCI-EORTC 2023.

Effect of MYC-Targeting Programmable Epigenomic mRNA Therapeutics on TME and Immunotherapy Responses.

Poster Presentation at ASCO 2023.

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